COVID-19: Unanswered questions on immune response and pathogenesis

Immune Response to the Pathogenesis of COVID-19 Infection: Possible Mechanism of Nutrition (Vitamins, Supplement) and Exercise

COVID-19 infection, a present ravaging disease attributed to a SARS-CoV like illness has brought the world to it knee causing a pandemic, with human-human transmission indexed to be a major source of transmission of this ailment. Alarmingly, this infection based on clinical manifestations has been diagnosed as a virus induced pneumonia with over 5 million cases reckoned at a mortality rate of a...

E-Learning: some unanswered questions

Genotype and phenotype of COVID-19: Their roles in pathogenesis

COVID-19 is a novel coronavirus with an outbreak of unusual viral pneumonia in Wuhan, China, and then pandemic. Based on its phylogenetic relationships and genomic structures the COVID-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have many similarities, but also have differences in their genomic and phenotypic structure that can influence th...

Significance of exosomes in COVID-19 pathogenesis and therapy

Exosomes are lipid bilayer-enclosed nano-sized vesicles, which carry various biomolecules including proteins, lipids, and microRNAs. SARS-CoV-2-loaded exosomes can be entered into the susceptible host cells, and transported viral components which are associated with viral particles intercellular transmission and spread of infection. Over-stimulation of the immune system followed by excessive pr...

Yoga: Some Unanswered Questions

Grover et al (1994) have provided an excellent and thought provoking analysis of the usefulness of yoga in treating neurotic disorders. Some questions however remain. One criticism of psychotherapy is that the criteria for the selection of suitable candidates usually identify patients with good prognostic features-patients who may improve even without any therapeutic intervention. Another criti...